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Catenin-α1/2 (P940) polyclonal antibody（KU）

货号: BS1040

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1040

Product Name :Catenin-α1/2 (P940) polyclonal antibody（KU）

Swiss-Prot :P35221/P26232

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF IP

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200 IP: 1:50~1:200

Background :a-catenins are a group of proteins associated with cadherin cell-cell adhesion molecules and play indispensable roles in the function of the cadherins. a N-catenin is a linker between cadherin adhesion receptors and the Actin cytoskeleton and is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. A deletion in this protein causes cerebellar and hippocampal lamination defects and impaired startle reaction. a E- and a N-catenin appear to co-localize in cell bodies of neurons in dorsal root ganglia. In mice, a N-catenin was found to occur at the roof plate of the mesencephalon and diencephalon, coinciding with Wnt-1 expression.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Catenin-α1/2 (P940) polyclonal antibody detects endogenous levels of Catenin-α1/2 protein.

BiowMW :~ 100 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Wntβ catenin signaling，Wntβ catenin signaling，Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13; CTNNA1; Catenin-α1; Catenin α1; αE-catenin; Catenin alpha-2; Alpha N-catenin; Alpha-catenin-related protein; CTNNA2; CAPR; Catenin-α2; Catenin α2; αN-catenin;

Immunogen :Synthetic peptide, corresponding to amino acids C-terminus of Human Catenin-α2.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of Catenin-α1/2 (P940) polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:COS-7 whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug) Lane5:CT26 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Catenin-α1/2 (P940) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Immunofluorescence analysis of MCF-7 cells using Catenin-α1/2 (P940) pAb at dilution of 1:200 (40x lens).

Immunoprecipitation of MCF-7 cell lysates using Catenin-α1/2 pAb (Sepharose Bead Conjugate)#BD0048 (lane 2 and lane 3) and Nonspecific IgG Control (Sepharose Bead Conjugate)#BD0048 (lane 4) .Lane 1 is 30% input. The western blot was probed using Catenin-α1/2 pAb.