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Caspase-8 (T341) polyclonal antibody（KU）

货号: AP0358

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :AP0358

Product Name :Caspase-8 (T341) polyclonal antibody（KU）

Swiss-Prot :Q14790

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Caspase 8 (T341) polyclonal antibody detects endogenous levels of full length caspase-8, the cleaved intermediate p43/p41 and the caspase-8 active fragment p18.

BiowMW :~ 18, 38, 55 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis,Necrotic Cell Death,Inhibition of Apoptosis,Toll-like Receptor signaling,Death Receptor Signaling,

Alternative Name :Caspase-8; Caspase8; Caspase 8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH; Caspase-8 subunit p18; Caspase-8 subunit p10; CASP8; MCH5

Immunogen :Synthetic peptide, corresponding to amino acids 310-362 of Human Caspase-8.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Caspase-8 (T341) polyclonal antibody at 1:500 dilution Lane1:sp2/0 cell lysate treated with colchicine(0.2ng/ml,15mins) Lane2:H9C2 cell lysate with colchicine(0.2ng/ml,15mins)

Western blot (WB) analysis of Caspase 8 (T341) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:HEK293T treated with Etoposide for 5min whole cell lysate(40ug) Lane3:HEK293T treated with Etoposide for 2h whole cell lysate(40ug) Lane4:HEK293T treated with Etoposide for 24h whole cell lysate(40ug)

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