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IL-4R/CD124(Tyr497) polyclonal antibody

货号: AP0210

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :AP0210

Product Name :IL-4R/CD124(Tyr497) polyclonal antibody

Swiss-Prot :P24394

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:1000~1:2000

Background :The IL-2 receptor is a multicomponent complex consisting of three subunits, α,β and γ, each of which is required for high affinity binding of IL-2. The α chainfunctions primarily in binding IL-2, whereas the β and γ chains contribute toIL-2 binding and are essential to IL-2-induced activation of signaling pathwaysleading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinity ligand-binding cytokine receptors. However, it is nowwell established that the IL-2Rγ chain functions as a second subunit of thehigh affinity IL-4R and IL-7R receptors. Consequently, the originally describedsubunits of these latter receptors are now referred to as IL-4Rα and IL-7Rα,respectively, while the common subunit is referred to as γc. Although the common γ chain enhances ligand binding in these three cytokine receptors, ithas no capacity to bind these ligands on its own. There is evidence that theγc chain is also a subunit of IL-13R.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL-4R/CD124(Tyr497) polyclonal antibody detects endogenous levels of HIST1H3A protein.

BiowMW :~ 85 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD_antigen: CD124; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; sIL4Ralpha/prot; IL-4-binding protein; IL4-BP; IL4R; 582J2.1

Immunogen :Synthetic peptide, corresponding to Human IL-4R/CD124(Tyr497).

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of IL-4R/CD124(Tyr497) polyclonal antibody at 1:2000 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:MCF-7 whole cell lysate(40ug) Lane3:HCT116 whole cell lysate(40ug)