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CD163 polyclonal antibody

货号: NCP0287P

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :NCP0287P

Product Name :CD163 polyclonal antibody

Swiss-Prot :Q86VB7

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :IF

Application_all :IF: 1:100~1:500

Background :CD163 is a transmembrane scavenger receptor expressed on the macrophage surface. It has 9 B-type Scavenger Receptor Cysteine-Rich (SRCR) extracellular domains mediating serum haptoglobin clearing/endocytosis, pathogen binding and signal transduction, and calcium binding. CD163 is used as a surface marker of M2 type macrophages, including M2 type tumor-associated macrophages (TAMs), which facilitate cancer progression by secreting cytokines to promote angiogenesis, immunosuppression, and metastasis. Inflammatory stimulation and stress signals can induce extracellular domain shedding of CD163 to generate soluble CD163 (sCD163). The increased sCD163 level in serum is associated with low-grade inflammation in disease conditions.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD163 polyclonal antibody detects endogenous levels of CD163 protein.

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :M130; CD163; Scavenger receptor cysteine-rich type 1 protein M130; Hemoglobin scavenger receptor; sCD163

Immunogen :Recombinant protein of human CD163.

Conjugate :Unconjugated

Modification :Unmodified

Immunofluorescence analysis of MG63 cells using CD163 pAb at dilution of 1:200 (40x lens).