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CD161 polyclonal antibody（KU）

货号: NCP0285P

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :NCP0285P

Product Name :CD161 polyclonal antibody（KU）

Swiss-Prot :Q12918

Host :Rabbit

Reactivity :Rat,Mouse,Human

Applications :WB IF

Application_all :WB: 1:5000~1:10000 IF 1:50~1:200

Background :Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD161 polyclonal antibody detects endogenous levels of CD161 protein.

BiowMW :~ 43 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD161

Immunogen :Recombinant protein of human CD161.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of CD161 polyclonal antibody at 1:5000 dilution Lane1:HEK293T cell membrane lysate(30ug) Lane2:MCF-7 cell membrane lysate(30ug) Lane3:CT-26 whole cell lysate(30ug) Lane4:PC12 whole cell lysate(30ug)

Immunofluorescence analysis of HEK293T cells using CD161 pAb at dilution of 1:200.