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CD119 polyclonal antibody（KU）

货号: NCP0255P

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :NCP0255P

Product Name :CD119 polyclonal antibody（KU）

Swiss-Prot :P15260

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :WB IF

Application_all :WB: 1:1000~1:2000 IF 1:50~1:200

Background :Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation Associates with transmembrane accessory factor IFNGR2 to form a functional receptor.Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription.STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity).

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD119 polyclonal antibody detects endogenous levels of CD119 protein.

BiowMW :~ 45-90 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Interferon gamma receptor 1; IFN-gamma receptor; IFN-gamma-R1; CDw119; Interferon gamma receptor alpha-chain; IFN-gamma-R-alpha; CD119

Immunogen :Recombinant protein of human CD119.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of CD119 polyclonal antibody at 1:1000 dilution Lane1:The Liver tissue lysate of Rat(30ug) Lane2:SP2/0 cell membrane lysate(30ug) Lane3:HepG2 whole cell lysate(30ug) Lane4:MCF-7 cell membrane lysate(30ug)