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IL7R/CD127 polyclonal antibody（KU）

货号: NCP0242P

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :NCP0242P

Product Name :IL7R/CD127 polyclonal antibody（KU）

Swiss-Prot :P16871

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IF

Application_all :WB: 1:5000~1:10000 IF 1:100 - 1:500

Background :The IL-7 receptor (IL-7R) is comprised of two protein subunits, CD127/IL-7Rα (IL-7Ralpha) and the common gamma chain (CD132), which is the major signaling component for several cytokines including IL-2, IL-4, IL-9, IL-15, and IL-21. CD127/IL-7Rα is a transmembrane protein belonging to the cytokine receptor homology class 1 (CRH1) and is expressed by a wide variety of cells including immature B cells, thymic natural killer cells, bone marrow stromal cells, and T cells. On its own, CD127/IL-7Rα functions as a receptor for two cytokine receptor complex signaling cascades: IL-7 and thymic stromal lymphopoietin (TSLP). IL-7 signaling contributes to T cell development and homeostasis whereas TSLP receptor signaling contributes to dendritic cell activation and B cell development. IL-7 signaling is an essential component in regulating the homeostasis of naive and memory T cells as differential expression of CD127/IL-7Rα is observed on naive and activated T cells, which occurs following TCR activation. Specifically, CD127/IL-7Rα expression is downregulated on activated T cells and the subsequent re-expression of CD127/IL-7Rα on these cells is indicative of cells that will differentiate into memory T cells. The A7R34 antibody is widely used to identify CD127/IL-7Rα expression on both B and T cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL7R/CD127 polyclonal antibody detects endogenous levels of IL7R/CD127 protein.

BiowMW :~ 65 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; CD127; Il7r

Immunogen :Recombinant protein of human IL7R/CD127.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of IL7R/CD127 polyclonal antibody at 1:5000 dilution Lane1:BV2 whole cell lysate(30ug) Lane2:Jurkat whole cell lysate(30ug)