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CD86 polyclonal antibody

货号: NCP0233P

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :NCP0233P

Product Name :CD86 polyclonal antibody

Swiss-Prot :P42081

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :IF

Application_all :IF: 1:100~1:500

Background :CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation. CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for naïve T cell activation, T cell proliferation, and acquisition of effector functions. Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD86 polyclonal antibody detects endogenous levels of CD86 protein.

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :T-lymphocyte activation antigen CD86; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD86; CD28LG2

Immunogen :Recombinant protein of human CD86.

Conjugate :Unconjugated

Modification :Unmodified

Immunofluorescence analysis of MG63 cells using CD86 pAb at dilution of 1:200 (40x lens).