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CD82 polyclonal antibody

货号: NCP0231P

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :NCP0231P

Product Name :CD82 polyclonal antibody

Swiss-Prot :P27701

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :IF

Application_all :IF: 1:200~1:800

Background :CD82 (KAI1) belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2). CD82 does not have enzymatic activity and appears to function by regulating the trafficking of other proteins and organization of the cell membrane. CD82 was originally described as a costimulator for T cells that directly associates with CD4 and CD8, and was subsequently identified during a screen as a metastasis suppressor in prostate cancer. CD82 has since been found to act as a metastasis suppressor in a variety of cancers, and its downregulation is associated with poor prognosis in research studies. CD82 suppresses metastasis through multiple mechanisms including inhibition of cell motility and invasion by modulating c-Met and the urokinase plasminogen activator surface receptor (uPAR), as well as promotion of homotypic cell-cell adhesion by stabilizing interactions between E-cadherin and β-catenin.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD82 polyclonal antibody detects endogenous levels of CD82 protein.

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CD82 antigen; C33 antigen; C33 antigen; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27 (Tspan-27); CD82

Immunogen :Recombinant protein of human CD82.

Conjugate :Unconjugated

Modification :Unmodified

Immunofluorescence analysis of Hela cells using CD82 pAb at dilution of 1:400 (40x lens).