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CD66/CEACAM1 polyclonal antibody

货号: NCP0220P

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :NCP0220P

Product Name :CD66/CEACAM1 polyclonal antibody

Swiss-Prot :P13688

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :IF

Application_all :IF: 1:100~1:500

Background :CEACAM1 (also known as C-CAM and CD66a) is a member of CEA-related cell-adhesion molecule (CEACAM) subfamily of the carcinoembryonic antigen (CEA) family. CEACAM1 is expressed by certain epithelial, endothelial, lymphoid, and myeloid cells. Human CEACAM1 has many different splice variants; the abundance of CEACAM1 and the relative ratio of the different isoforms varies markedly among cell types and may be regulated in a context-dependent fashion. The isoforms with long (L) and short (S) cytoplasmic tails have different signaling properties. Notably, L isoforms contain a functional ITIM (immunoreceptor tyrosine-based inhibitory motif) and several serine and threonine residues that could serve as potential phosphorylation targets. The extracellular domain of CEACAM1 is heavily glycosylated, making its apparent molecular weight during electrophoresis much larger than its predicted size (57.6 kDa). CEACAM1 mediates intercellular adhesion through homo- and heterophilic interaction with other members of the CEACAM family. Studies indicate that CEACAM1 plays important roles in angiogenesis, neovascularization, insulin signaling, T cell signaling, and tumorigenesis. In addition, CEACAM1 can function as a receptor for several microbial pathogens.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD66/CEACAM1 polyclonal antibody detects endogenous levels of CD66/CEACAM1 protein.

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Carcinoembryonic antigen-related cell adhesion molecule 1; Biliary glycoprotein 1; BGP-1; CD66a; CEACAM1; BGP; BGP1

Immunogen :Recombinant protein of human CD66/CEACAM1.

Conjugate :Unconjugated

Modification :Unmodified

Immunofluorescence analysis of MG63 cells using CCD66/CEACAM1 pAb at dilution of 1:200 (40x lens).