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CD5 polyclonal antibody

货号: NCP0214P

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :NCP0214P

Product Name :CD5 polyclonal antibody

Swiss-Prot :P06127

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :IF

Application_all :IF: 1:100~1:500

Background :CD5 is a type-I transmembrane protein belonging to the scavenger receptor cysteine-rich (SRCR) family, characterized by the presence of at least one SRCR domain of 90-110 amino acids. CD5 is expressed by all mature T cells, the B-1a subset of mature B cells, and some leukemic B cells. Its expression is increased in regulatory T and B cells (Tregs/Bregs). Anergic T and B cells also have elevated CD5 expression. Elevated levels of CD5 are also found in many autoimmune disorders. CD5 is associated with the T cell receptor (TCR) and negatively modulates T cell activation and differentiation. CD5 expression on the tumor infiltrating T lymphocytes is inversely correlated with their antitumor activity. Recently, it was reported that CD5 directly binds to IL6 and can mediate downstream signaling. CD5+ B cells promote tumor growth in animal models. Reagents targeting CD5 have been actively pursued as therapeutic interventions for cancer and other conditions.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD5 polyclonal antibody detects endogenous levels of CD5 protein.

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :T-cell surface glycoprotein CD5; LEU1; Lymphocyte antigen T1/Leu-1; CD5

Immunogen :Recombinant protein of human CD5.

Conjugate :Unconjugated

Modification :Unmodified

Immunofluorescence analysis of MG63 cells using CD5 pAb at dilution of 1:200 (40x lens).