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CD253 polyclonal antibody

货号: NCP0194P

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :NCP0194P

Product Name :CD253 polyclonal antibody

Swiss-Prot :P50591

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :IF

Application_all :IF: 1:100~1:500

Background :Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also referred to as Apo2 ligand, first identified based on its sequence homology to TNF and Fas/Apo ligand is a member of the TNF family of cytokines and either exists as a type II membrane or soluble protein. TRAIL induces apoptosis in a variety of transformed cell lines and plays a role in anti-tumor and anti-viral immune surveillance. TRAIL signals via binding with death receptors DR4 (TRAIL-R1) and DR5 (TRAIL-R2) which can trigger apoptosis as well as NF-κB activation. Death domains on these receptors leads to the recruitment of a death-induced signaling complex (DISC) leading to caspase-8 and subsequent caspase-3 activation. In addition, TRAIL binds with decoy receptors DcR1 (TRAIL-R3) and DcR2 (TRAIL-R4, TRUNDD) which lack the functional cytoplasmic death domain antagonizing TRAIL-induced apoptosis. Osteoprotegerin (OPG) has also been identified as receptor capable of inhibiting TRAIL-induced apoptosis. The selectivity of soluble TRAIL at triggering apoptosis in transformed cells as compared to normal cells has led to its investigation as a potential cancer therapeutic.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD253 polyclonal antibody detects endogenous levels of CD253 protein.

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TL2; APO2L; CD253; TANCR; TRAIL; Apo-2L; TNLG6A

Immunogen :Recombinant protein of human CD253.

Conjugate :Unconjugated

Modification :Unmodified

Immunofluorescence analysis of MG63 cells using CD253 pAb at dilution of 1:200 (40x lens).