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CD105 polyclonal antibody（KU）

货号: NCP0171P

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :NCP0171P

Product Name :CD105 polyclonal antibody（KU）

Swiss-Prot :P17813

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IF

Application_all :WB: 1:1000~1:2000 IF 1:100 - 1:500

Background :Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis .Required for normal structure and integrity of adult vasculature .Regulates the migration of vascular endothelial cells .Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity).May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity).May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors .Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors .Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD105 polyclonal antibody detects endogenous levels of CD105 protein.

BiowMW :~90 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Endoglin; CD105

Immunogen :Recombinant protein of human CD105.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of CD105 polyclonal antibody at 1:1000 dilution Lane1:MCF-7 cell membrane lysate(20ug) Lane2:A549 cell membrane lysate(30ug)

Western blot (WB) analysis of CD105 polyclonal antibody at 1:1000 dilution Lane1:A549 whole cell lysate(40ug) Lane2:CT-26 whole cell lysate(40ug)

Immunofluorescence analysis of MG63 cells using CD105 pAb at dilution of 1:200 (40x lens).