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SQSTM1 Mouse monoclonal antibody

货号: MB9009

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB9009

Product Name :SQSTM1 Mouse monoclonal antibody

Swiss-Prot :Q13501

Host :Mouse

Reactivity :Human,Monkey,Mouse,Rat

Applications :FC, IHC, WB

Application_all :WB 1:500~2000 IHC 1:150 FLOW 1:100

Background :Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress and autophagy. It was first identified as a protein that binds to the SH2 domain of p56Lck and independently found to interact with PKCζ. SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome. Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-κB pathway. It may play a role in titin/TTN downstream signaling in muscle cells and regulate signaling cascades through ubiquitination. P62 may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of SQSTM1 and does not cross-react with related proteins.

BiowMW :~ 62 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Sequestosome-1; EBI3-associated protein of 60 kDa; EBIAP; p60; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62; SQSTM1; ORCA; OSIL

Immunogen :Full length human recombinant protein of human SQSTM1 (NP_003891) produced in HEK293T cell.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of SQSTM1 Mouse mAb at 1:500 dilution

Immunohistochemical analysis of paraffin-embedded Human pancreas tissue using anti-SQSTM1 antibody. Counter stained with hematoxylin.

Immunohistochemical analysis of paraffin-embedded Human thyroid tissue using anti-SQSTM1 antibody. Counter stained with hematoxylin.

Immunohistochemical analysis of paraffin-embedded Human prostate tissue using anti-SQSTM1 antibody. Counter stained with hematoxylin.

Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophages

JournalBiochimica Et Biophysica Acta-Molecular Basis Of Disease

ApplicationWB

IF4.352

SpeciesHuman

PMID29859240
Myocardial structure and functional alterations in a preclinical model of exertional heat stroke

JournalLIFE SCIENCES

ApplicationIF

IF6.78

SpeciesRat

PMID37004732