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TfR1/CD71 (5C9) monoclonal antibody

货号: MB8615

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :MB8615

Product Name :TfR1/CD71 (5C9) monoclonal antibody

Swiss-Prot :P02786

Host :Mouse

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C terminal binding site. The antigen is present on most dividing cells, including normally cycling in vivo hematopoietic progenitor cells, mitogenically stimulated cells in vitro, some primary tumor cells and most proliferating cells in vitro.The transferrin receptor has been structurally characterized as a sulfide bound dimer of identical glycoprotein subunits of 95 kDa.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD71 monoclonal antibody detects endogenous levels of CD71 protein.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; p90; CD71; Transferrin receptor protein 1, serum form; sTfR; TFRC

Immunogen :A synthetic peptide corresponding to residues in Human CD71.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CD71 monoclonal antibody at 1:500 dilution Lane1:RAW264.7 whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug)

Long-Term High-Fat Diet Decreases Hepatic Iron Storage Associated with Suppressing TFR2 and ZIP14 Expression in Rats

JournalJournal Of Agricultural And Food Chemistry

ApplicationWB

IF4.192

SpeciesRat

PMID30350980
Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma

JournalJournal of Orthopaedic Surgery and Research

ApplicationIHC

IF1.907

SpeciesHuman

PMID31484533