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RCC1 monoclonal antibody

货号: MB66914

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66914

Product Name :RCC1 monoclonal antibody

Swiss-Prot :P18754

Host :Mouse

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/1000 - 1/2000)

Background :The Ras family small GTPase Ran is involved in nuclear envelope formation, assembly of the mitotic spindle, and nuclear transport . Like other small GTPases, Ran is active in its GTP-bound form and inactive in its GDP-bound form. Nuclear RanGTP concentration is maintained through nuclear localization of guanine nucleotide exchange factor activity, which catalyzes the exchange of bound GDP for GTP. Regulator of chromatin condensation 1 is the only known RanGEF . RCC1 is dynamically chromatin-bound throughout the cell cycle, and this localization is required for mitosis to proceed normally. Appropriate association of RCC1 with chromatin is regulated through amino-terminal phosphorylation and methylation. RCC1 regulation of RanGTP levels in response to histone modifications regulates nuclear import during apoptosis . In mitosis RCC1 is phosphorylated at Ser11, possibly by cyclin B/cdc2 . This phosphorylation may play a role in RCC1 interaction with chromatin and RCC1 RanGEF activity .

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of RCC1 protein.

BiowMW :~ 45 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CHC1; Regulator of chromosome condensation; Cell cycle regulatory protein; Chromosome condensation protein 1

Immunogen :Recombinant fusion protein of human RCC1. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of RCC1 expression in Hela (A), HL60 (B), COS7 (C), C2C12 (D) whole cell lysates.

免疫沉淀（IP）