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Gamma-catenin monoclonal antibody

货号: MB66888

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66888

Product Name :Gamma-catenin monoclonal antibody

Swiss-Prot :P14923

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Also known as plakoglobin, 纬-catenin is a member of the Armadillo family of signaling molecules, which includes 尾-catenin and the聽Drosophila聽protein armadillo . This family of proteins is involved in Wnt signaling, which is important in embryonic development and in tumorigenesis . Although the two vertebrate proteins 尾- and 纬-catenin display sequence homology, 纬-catenin likely plays a role distinct from that of 尾-catenin . 纬-catenin localizes to desmosomes and adherens junctions, both sites of intercellular adhesion, and interacts with the cytoplasmic domains of classical and desmosomal cadherins. Interaction of 纬- or 尾-catenin with 伪-catenin, desmoplakin and other junction proteins provides a link between intercellular junctions and the actin and intermediate filament cytoskeleton. Maintenance and/or modification of this link is vital for control of cell adhesion and migration . 纬-catenin is modified by phosphorylation, affecting both adhesion and 尾-catenin dependent transcription , and by and O-glycosylation, affecting adhesion . Recent evidence suggests that 纬-catenin regulates desmosomal adhesion in response to growth factor stimulation .

Product :Mouse IgG3. Supplied in crude ascites with 0.01% sodium azide.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Gamma-catenin protein.

BiowMW :~ 83 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Adherens Junction signaling

Alternative Name :CTNNG; DP3; Junction plakoglobin; Catenin gamma; Desmoplakin III; Desmoplakin-3

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Gamma-catenin. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Gamma-catenin expression in NCIH292 (A) whole cell lysates.