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ETS1 monoclonal antibody

货号: MB66887

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66887

Product Name :ETS1 monoclonal antibody

Swiss-Prot :P14921

Host :Mouse

Reactivity :Human

Applications :WB, FC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/10 - 1/50)

Background :ETS-1 is a proto-oncoprotein that belongs to the E26 Transformation-specific Sequence family of transcription factors that share a unique and highly conserved DNA binding domain . ETS-1 plays important roles in vascular development and angiogenesis, and vascular inflammation and remodeling . The target genes of ETS-1 include receptor tyrosine kinases, MMPs, and cell adhesion molecules . In addition, ETS-1 is involved in regulation of energy metabolism in cancer cells . ETS-1 activity is regulated by two different types of phosphorylation sites. While phosphorylation at a cluster of serine residues in the exon VII domain by CaMKII inhibits ETS-1 DNA binding activity , phosphorylation at its Thr38 site by Ras activates ETS-1 .

Product :Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of ETS1 protein.

BiowMW :~ 56 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :T cell receptor signaling,G Protein-coupled Receptors Signaling to MAPK Erk,Signaling Pathways Activating p38 MAP Kinase

Alternative Name :EWSR2; Protein C-ets-1; p54

Immunogen :Recombinant fusion protein of human ETS1. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of ETS1 expression in MOLT4 (A) whole cell lysates.