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Von Willebrand Factor monoclonal antibody

货号: MB66796

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66796

Product Name :Von Willebrand Factor monoclonal antibody

Swiss-Prot :P04275

Host :Mouse

Reactivity :Human

Applications :WB, FC

Application_all :WB (1/500 - 1/1000)

Background :Von Willebrand disease is a congenital bleeding disorder caused by defects in the von Willebrand factor protein (VWF). VWF is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets, and it is involved in the coagulation of blood at injury sites. VWF acts as a carrier protein for Factor VIII, a cofactor required for coagulation, and it promotes platelet adhesion and aggregation. Several factors are known to stimulate the binding of VWF to platelets, including glycoprotein 1b, ristocetin, botrocetin, collagen, sulphatides and heparin. Of the several domains contained within VWF, the A1, A2 and A3 domains have been shown to mediate this activation. VWF is thought to undergo a variety of posttranslational modifications that influence the affinity and availability for Factor VII, including cleavage of the propeptide and formation of N-terminal intersubunit disulfide bonds.

Product :Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Von Willebrand Factor protein.

BiowMW :~ 310 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :F8VWF; von Willebrand factor; vWF

Immunogen :Recombinant fusion protein of human Von Willebrand Factor. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Von Willebrand Factor expression in VWF protein (A) whole cell lysates.

免疫沉淀（IP）