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Lamin A/C monoclonal antibody

货号: MB66775

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66775

Product Name :Lamin A/C monoclonal antibody

Swiss-Prot :P02545

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/1000 - 1/2000)

Background :A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed CED-3/ICE, is comprised of ICE, CPP32, ICH-1/Nedd-2, Tx, Mch2, Mch3 (ICE-LAP3 or CMH-1), Mch4 and ICE-LAP6. Ced-3/ICE family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology. The nuclear Lamin A is cleaved by Mch2, but not CPP32. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family. Lamin C is a splice variant of Lamin A, differing only at the carboxy-terminus. Lamins A and C are identical for the first 566 amino acids, with Lamin C differing only in six unique carboxy-terminal amino acids.

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Lamin A/C protein.

BiowMW :~ 72 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Death Receptor Signaling,PI3K AKT signaling

Alternative Name :LMN1; Prelamin-A/C

Immunogen :Recombinant fusion protein of human Lamin A/C. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Lamin A/C expression in Hela (A), C6 (B), L929 (C), NIH3T3 (D) whole cell lysates.