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IL-1 beta monoclonal antibody

货号: MB66768

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB66768

Product Name :IL-1 beta monoclonal antibody

Swiss-Prot :P01584

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/1000 - 1/2000)

Background :Two forms of interleukin-1, designated IL-1a and IL-1b, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1a and IL-1b bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1b for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.

Product :Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of IL-1 beta protein.

BiowMW :~ 35 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :IL1F2; Interleukin-1 beta; IL-1 beta; Catabolin

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-1 beta. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of IL-1 beta expression in 293 cells transfected with IL1B (A) whole cell lysates.

免疫沉淀（IP）

免疫组织化学（IHC）