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c-Myc monoclonal antibody

货号: MB66759

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66759

Product Name :c-Myc monoclonal antibody

Swiss-Prot :P01106

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation,differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region, provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein, designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibits appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad 1 and Mxi1, and Mad 1-Max dimers have been shown to repress transcription through interaction with mSin3.

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of c-Myc protein.

BiowMW :~ 57 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Cell Cycle Control G1 S Checkpoin,MAPK Erk in Growth and Differentiation Pathway,Signaling Pathways Activating p38 MAP Kinase,Warburg Effect

Alternative Name :BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64

Immunogen :Recombinant fusion protein of human c-Myc. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of c-Myc expression in Hela (A), K562 (B), Jurkat (C), Raji (D), LNCaP (E) whole cell lysates.