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BCL10 monoclonal antibody

货号: MB66748

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66748

Product Name :BCL10 monoclonal antibody

Swiss-Prot :O95999

Host :Mouse

Reactivity :Human

Applications :WB, IHC, FC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200), FC (1/10 - 1/50)

Background :Bcl10, also designated CIPER, c-CARMEN and mE10, was first identified as a gene truncated or mutated in MALT B cell lymphomas and other tumor types.Bcl10 is homologous to the equine herpes virus-2 E10 gene, and like E10 it contains an amino-terminal caspase recruitment domain (CARD). Expression of Bcl10 was shown to induce NFκB activation in a NIK-dependent pathway, and the CARD domain was shown to be essential for this activation. In a separate study, Bcl10 by itself did not induce JNK or NFκB activation. Overexpression of Bcl10 was shown to induce apoptosis, in a manner that was dependent on CARD-mediated oligomerization. Bcl10 was also shown to play a role in processing of caspase-9 to its active dimer. Other studies have shown that Bcl10 is not mutated in many human tumors and lymphomas.

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of BCL10 protein.

BiowMW :~ 28 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :T cell receptor signaling

Alternative Name :CIPER; CLAP; B-cell lymphoma/leukemia 10; B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10; mE10

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BCL10. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of BCL10 expression in Daudi (A) whole cell lysates.

Immunohistochemical analysis of BCL10 staining in human kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.