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Beta-catenin monoclonal antibody

货号: MB66700

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66700

Product Name :Beta-catenin monoclonal antibody

Swiss-Prot :P35222

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :β-catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Beta-catenin protein.

BiowMW :~ 92 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Adherens Junction signaling, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, Wntβ catenin signaling.

Alternative Name :CTNNB; Catenin beta-1; Beta-catenin

Immunogen :Purified recombinant human β-Catenin protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Beta-catenin expression in HCT116 (A), C6 (B), NIH3T3 (C) whole cell lysates.