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Lamin A/C monoclonal antibody

货号: MB66688

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66688

Product Name :Lamin A/C monoclonal antibody

Swiss-Prot :P02545

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100)

Background :Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear dysregulation and cell death.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Lamin A/C protein.

BiowMW :~ 74, 63 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Death Receptor Signaling, PI3K AKT signaling.

Alternative Name :LMN1; Prelamin-A/C

Immunogen :Purified recombinant human LMNA protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Lamin A/C expression in MCF7 (A), A549 (B), Hela (C) whole cell lysates.