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EGFR monoclonal antibody

货号: MB66686

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66686

Product Name :EGFR monoclonal antibody

Swiss-Prot :P00533

Host :Mouse

Reactivity :Human, Monkey

Applications :WB, IF/ICC, IP

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100), IP (1/10 - 1/50)

Background :The epidermal growth factor (EGF) receptor is a 170 kDa transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Research studies have shown that somatic mutations in the tyrosine kinase domain of EGF receptor (EGFR) are present in a subset of lung adenocarinomas that respond to EGFR inhibitors, such as gefinitib and erlotinib. Two types of mutations account for approximately 90% of mutated cases: a specific point mutation, L858R, that occurs in exon 21 and short in-frame deletions in exon 19. The most frequent exon 19 deletion is E746-A750, accounting for 90% of lesions at this site, although some rare variants occur.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of EGFR protein.

BiowMW :~ 175 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis, ErbB HER Signaling, Jak Stat ：IL-6 Receptor Signaling, Phospholipase Signaling.

Alternative Name :ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1

Immunogen :Purified recombinant human EGFR protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of EGFR expression in A549 (A), COS7 (B) whole cell lysates.