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OMI monoclonal antibody

货号: MB66681

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66681

Product Name :OMI monoclonal antibody

Swiss-Prot :O43464

Host :Mouse

Reactivity :Human

Applications :WB, IP

Application_all :WB (1/500 - 1/1000), IP (1/10 - 1/50)

Background :High temperature requirement protein A2 (HtrA2)/Omi is a serine protease with homology to the E. coli HtrA protein (DegP) and is thought to be involved in apoptosis and stress-induced degradation of misfolded proteins. While HtrA2 was orignally identified to be present in either the nucleus or endoplasmic reticulum, subsequent studies have shown that it localizes in mitochondria and is released during apoptosis. HtrA2 is produced as a 50 kDa zymogen that is cleaved to generate a 36 kDa mature protein that exposes an amino terminal motif (AVPS) resembling that of the IAP inhibitor Smac/Diablo. Like Smac, interaction between HtrA2 and IAP family members, such as XIAP, antagonizes their inhibition of caspase activity and protection from apoptosis. Interestingly, HtrA2 knock-out mice did not show signs of reduced apoptosis, but rather had a loss of neurons in the striatum and a Parkinson's-like phenotype, suggesting that HtrA2 might have a neuroprotective function. This activity is associated with the protease activity of HtrA2. Furthermore, research studies have shown that loss of function mutations in the HtrA2 gene are associated with Parkinson's disease.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of OMI protein.

BiowMW :~ 36 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis,Death Receptor Signaling,Mitochondrial Control of Apoptosis.

Alternative Name :OMI; PRSS25; Serine protease HTRA2 mitochondrial; High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; Serine protease 25; Serine proteinase OMI

Immunogen :Recombinant human HtrA2/Omi protein.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of OMI expression in 293T (A) whole cell lysates.