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GRB2 monoclonal antibody

货号: MB66663

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66663

Product Name :GRB2 monoclonal antibody

Swiss-Prot :P62993

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Growth factor receptor-binding protein 2 (GRB2) is an adaptor protein that is involved in RTK signal transduction. The SH2 domain of GRB2 binds to tyrosine phosphorylated proteins such as EGFR, IRS-1, Shc and Gab1. The SH3 domain of GRB2 associates with Sos, which stimulates the GTP binding activity of Ras, leading to the activation of the MAP kinase and other signaling pathways. Phosphorylation of Tyr209 of GRB2 by Bcr-Abl and EGFR abolishes its association with Sos and negatively regulates downstream signaling.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of GRB2 protein.

BiowMW :~ 25 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics, ErbB HER Signaling, G Protein-coupled Receptors Signaling to MAPK Erk, Jak Stat ：IL-6 Receptor Signaling, Insulin &Glucose Signaling, SAPK JNK Signaling Cascades, T cell receptor signaling, TGFβ Smad signaling.

Alternative Name :ASH; Growth factor receptor-bound protein 2; Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2

Immunogen :Recombinant protein of human GRB2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of GRB2 expression in K562 (A), Raji (B), Jurkat (C), Ramos (D), C6 (E), NIH3T3 (F), Hela (G) whole cell lysates.