Product Name :GSK3 beta monoclonal antibody
Reactivity :Human, Mouse, Rat
Applications :WB, IHC, FC
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/100), FC (1/50 - 1/100)
Background :Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.
Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of GSK3 beta protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Adherens Junction signaling, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer\'s Disease, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, Cell Cycle Control G1 S Checkpoin, MAPK Erk in Growth and Differentiation Pathway, Hedgehog Signaling, Inhibition of Apoptosis, Insulin &Glucose Signaling, Regulation of Microtubule Dynamics, NF-kB Signaling, PI3K AKT signaling, Translational Contral Regulation of elF2, Translational Contral elF4 and p70 S6 Kinase, Wntβ catenin signaling, MTOR signaling.
Alternative Name :Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
Immunogen :Purified recombinant fragment of human GSK3B (AA: 2-159) expressed in E. Coli.
Modification :Unmodification
