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PYK2 monoclonal antibody

货号: MB66631

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66631

Product Name :PYK2 monoclonal antibody

Swiss-Prot :Q14289

Host :Mouse

Reactivity :Human

Applications :WB, IHC

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/100)

Background :Protein tyrosine kinase Pyk2, also called CAKβ, RAFTK and CADTK, is a nonreceptor tyrosine kinase structurally related to focal adhesion kinase (FAK). Pyk2 is predominantly expressed in cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for the G-protein-coupled receptors and MAP kinase signaling pathway. It plays an important role in cell spreading and migration.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of PYK2 protein.

BiowMW :~ 116 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :G-Protein-Coupled Receptors Signaling to MAPK/Erk, MAPK/Erk in Growth and Differentiation.

Alternative Name :FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Related adhesion focal tyrosine kinase; RAFTK

Immunogen :Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of PYK2 expression in A549 (A), Ramos (B), Jurkat (C), THP1 (D), Raji (E) whole cell lysates.

Immunohistochemical analysis of PYK2 staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.139). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.