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BID monoclonal antibody

货号: MB66626

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66626

Product Name :BID monoclonal antibody

Swiss-Prot :P55957

Host :Mouse

Reactivity :Human

Applications :WB, IF/ICC, FC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100), FC (1/50 - 1/100)

Background :Bid is a pro-apoptotic “BH3 domain-only” member of the Bcl-2 family originally discovered to interact with both the anti-apoptotic family member Bcl-2 and the pro-apoptotic protein Bax. Bid is normally localized in the cytosolic fraction of cells as an inactive precursor and is cleaved at Asp60 by caspase-8 during Fas signaling, leading to translocation of the carboxyl terminal p15 fragment (tBid) to the mitochondrial outer membrane. Translocation of Bid is associated with release of cytochrome c from the mitochondria, leading to complex formation with Apaf-1 and caspase-9 and resulting in caspase-9 activation. Thus, Bid relays an apoptotic signal from the cell surface to the mitochondria triggering caspase activation.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of BID protein.

BiowMW :~ 22 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis.

Alternative Name :BH3-interacting domain death agonist; p22 BID; BID

Immunogen :Purified recombinant fragment of human BID expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of BID expression in 293T (A), Jurkat (B), A431 (C) whole cell lysates.