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RPS6 monoclonal antibody

货号: MB66614

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66614

Product Name :RPS6 monoclonal antibody

Swiss-Prot :P62753

Host :Mouse

Reactivity :Human, Mouse, Rat, Monkey

Applications :WB, IF/ICC, IP

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100), IP (1/10 - 1/50)

Background :One way that growth factors and mitogens effectively promote sustained cell growth and proliferation is by upregulating mRNA translation. Growth factors and mitogens induce the activation of p70 S6 kinase and the subsequent phosphorylation of S6 ribosomal protein. Phosphorylation of S6 ribosomal protein correlates with an increase in translation of mRNA transcripts that contain an oligopyrimidine tract in their 5' untranslated regions. These particular mRNA transcripts (5'TOP) encode proteins involved in cell cycle progression, as well as ribosomal proteins and elongation factors necessary for translation. Important S6 ribosomal protein phosphorylation sites include several residues (Ser235, Ser236, Ser240, and Ser244) located within a small, carboxy-terminal region of S6 protein.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of RPS6 protein.

BiowMW :~ 32 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :PI3K AKT signaling，Translational Contral elF4 and p70 S6 Kinase

Alternative Name :40S ribosomal protein S6; Phosphoprotein NP33

Immunogen :Synthetic peptide derived from human S6 Ribosomal Protein.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of RPS6 expression in Ramos (A), Jurkat (B), C6 (C), NIH3T3 (D), Hela (E) whole cell lysates.