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Lamin B1 monoclonal antibody

货号: MB66605

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66605

Product Name :Lamin B1 monoclonal antibody

Swiss-Prot :P20700

Host :Mouse

Reactivity :Human, Mouse, Monkey

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100)

Background :Lamins are nuclear membrane structural components that are important in maintaining normal cell functions, such as cell cycle control, DNA replication, and chromatin organization. Lamins have been subdivided into types A and B. Type-A lamins consist of lamin A and C, which arise from alternative splicing of the lamin A gene LMNA. Lamin A and C are cleaved by caspases into large (41-50 kDa) and small (28 kDa) fragments, which can be used as markers for apoptosis. Type-B lamins consist of lamin B1 and B2, encoded by separate genes. Lamin B1 is also cleaved by caspases during apoptosis. Research studies have shown that duplication of the lamin B1 gene LMNB1 is correlated with pathogenesis of the neurological disorder adult-onset leukodystrophy.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Lamin B1 protein.

BiowMW :~ 66 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :LMN2; LMNB; Lamin-B1

Immunogen :Recombinant human Lamin B1 protein.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Lamin B1 expression in COS7 (A), Molt4 (B), A549 (C), NIH3T3 (D) whole cell lysates.

免疫沉淀（IP）