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CREB monoclonal antibody

货号: MB66602

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66602

Product Name :CREB monoclonal antibody

Swiss-Prot :P16220

Host :Mouse

Reactivity :Human, Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways, including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of CREB protein.

BiowMW :~ 43 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ErbB HER Signaling，Inhibition of Apoptosis，Signaling Pathways Activating p38 MAP Kinase

Alternative Name :Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1

Immunogen :Purified recombinant human CREB protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CREB expression in Jurkat (A), A549 (B), MCF7 (C), C6 (D), Hela (E) whole cell lysates.