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TAK1 monoclonal antibody

货号: MB66585

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66585

Product Name :TAK1 monoclonal antibody

Swiss-Prot :O43318

Host :Mouse

Reactivity :Human, Mouse, Rat, Monkey

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :TAK1 is a mitogen-activated protein kinase kinase kinase that can be activated by TGF-β, bone morphogenetic protein and other cytokines including IL-1. In vivo activation of TAK1 requires association with TAK1 binding protein 1 (TAB1), which triggers phosphorylation of TAK1. Another adaptor protein, TAB2, links TAK1 with TRAF6 and mediates TAK1 activation upon IL-1 stimulation. Once activated, TAK1 phosphorylates MAPK kinases MKK4 and MKK3/6, which activate p38 MAPK and JNK, respectively. In addition, TAK1 activates the NF-κB pathway by interacting with TRAF6 and phosphorylating the NF-κB inducing kinase (NIK).

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of TAK1 protein.

BiowMW :~ 75 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics，Regulation of Apoptosis，G Protein-coupled Receptors Signaling to MAPK Erk，Inhibition of Apoptosis，NF-kB Signaling，SAPK JNK Signaling Cascades，TGFβ Smad signaling，Toll-like Receptor signaling，Wntβ catenin signaling

Alternative Name :TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1

Immunogen :Purified recombinant human TAK1 protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of TAK1 expression in K562 (A), Hela (B), MCF7 (C), COS7 (D), NIH3T3 (E), C6 (F) whole cell lysates.