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cIAP2 monoclonal antibody

货号: MB66548

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB66548

Product Name :cIAP2 monoclonal antibody

Swiss-Prot :Q13489

Host :Mouse

Reactivity :Human, Monkey

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain. Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression. In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9. In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of cIAP2 protein.

BiowMW :~ 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis，Death Receptor Signaling，Inhibition of Apoptosis

Alternative Name :API2; IAP1; MIHC; RNF49; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2; C-IAP2; IAP homolog C; Inhibitor of apoptosis protein 1; IAP-1; hIAP-1; hIAP1; RING finger protein 49; TNFR2-TRAF-signaling complex protein 1

Immunogen :Purified recombinant human c-IAP2 protein fragments expressed in E.coli

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of cIAP2 expression in Ramos (A), COS7 (B), Raji (C), Daudi (D) whole cell lysates.