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SWAP-70 monoclonal antibody

货号: MB66544

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66544

Product Name :SWAP-70 monoclonal antibody

Swiss-Prot :Q9UH65

Host :Mouse

Reactivity :Human, Mouse, Rat, Monkey

Applications :WB, IP

Application_all :WB (1/500 - 1/1000), IP (1/10 - 1/50)

Background :SWAP70 is a Rac family guanine nucleotide exchange factor (GEF). It is highly expressed by activated B cells. Following B cell stimulation, SWAP70 has been observed to translocate from the cytoplasm to the nucleus, where it plays a role in class switching, as well as to the membrane, where it associates with the B cell receptor. SWAP70 also plays a role in migration of B cells and other immune cell types including dendritic cells, eosinophils, and mast cells. Mice deficient in both SWAP70 and a related protein, DEF6, develop lupus-like autoimmunity due to misregulation of IRF4 in B cells and T cells leading to increased IL21 production and responsiveness.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of SWAP-70 protein.

BiowMW :~ 65 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA0640; Switch-associated protein 70; SWAP-70

Immunogen :Purified recombinant human SWAP70 protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of SWAP-70 expression in COS7 (A), 293T (B), C6 (C), NIH3T3 (D), Hela (E) whole cell lysates.

免疫沉淀（IP）