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FYN monoclonal antibody

货号: MB66526

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB66526

Product Name :FYN monoclonal antibody

Swiss-Prot :P06241

Host :Mouse

Reactivity :Human, Mouse, Rat, Monkey

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100)

Background :The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells. Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregulates enzyme activity, phosphorylation at Tyr527 in the carboxy-terminal tail by Csk renders the enzyme less active.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of FYN protein.

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis，Regulation of Actin Dynamics，ErbB HER Signaling，Jak Stat ：IL-6 Receptor Signaling，Inhibition of Apoptosis，Regulation of Microtubule Dynamics，PI3K AKT signaling，Wntβ catenin signaling

Alternative Name :Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn

Immunogen :Purified recombinant human Fyn protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of FYN expression in Hela (A), NIH3T3 (B), C6 (C), COS7 (D), CEM (E), Ramos (F), Jurkat (G) whole cell lysates.