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hnRNP U monoclonal antibody

货号: MB66525

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66525

Product Name :hnRNP U monoclonal antibody

Swiss-Prot :Q00839

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :hnRNP U, also known as scaffold attachment factor A (SAF-A) or SP120, was first described as a nuclear matrix protein that contributes to RNA metabolism. hnRNP U has been shown to bind pre-mRNAs and contributes to splicing by controlling U2 snRNP maturation . Furthermore, hnRNP U has been shown to bind chromatin to help regulate its structure during interphase. During prophase, hnRNP U becomes phosphorylated by Aurora-B, which evicts hnRNP U and the chromatin-associated RNAs bound to it, a process critical to proper chromosome alignment. hnRNP U plays a role in the chromatin localization of Xist RNA, and loss of hnRNP U in ES cells fail to achieve an inactivated X chromosome. hnRNP U has also been shown to play a key role in immunity, functioning as a viral dsRNA sensor. Upon viral recognition, hnRNP U oligomerizes and activates numerous antiviral genes, including IFNB1 . Loss of function variants of hnRNP U have been shown to cause early onset epilepsy and intellectual disorders.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of hnRNP U protein.

BiowMW :~ 125 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :HNRPU; SAFA; U21.1; Heterogeneous nuclear ribonucleoprotein U; hnRNP U; Scaffold attachment factor A; SAF-A; p120; pp120

Immunogen :Purified recombinant human hnRNP U protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of hnRNP U expression in K562 (A), Jurkat (B), Hela (C) whole cell lysates.

免疫沉淀（IP）