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Aurora A monoclonal antibody

货号: MB66513

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66513

Product Name :Aurora A monoclonal antibody

Swiss-Prot :O14965

Host :Mouse

Reactivity :Human, Monkey

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100)

Background :Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines . Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis . The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events , and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Aurora A protein.

BiowMW :~ 48 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune checkpoint signaling in the Tumor Microenvironment

Alternative Name :AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6; Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A

Immunogen :Purified recombinant human Aurora Kinase A protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Aurora A expression in SW480 (A), COS7 (B) whole cell lysates.