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PP1 alpha monoclonal antibody

货号: MB66507

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66507

Product Name :PP1 alpha monoclonal antibody

Swiss-Prot :P62136

Host :Mouse

Reactivity :Human

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100)

Background :Type 1 protein phosphatase (PP1), a serine/threonine phosphatase, is highly conserved in eukaryotic cells. Four isoforms of PP1 have been characterized: PP1α, PP1δ, PP1γ1 and PP1γ2 . Involvement in cell cycle regulation is one of the biological functions of PP1 . It has been illustrated that PP1 dephosphorylates Rb and cdc25 during mitosis . A cell cycle-dependent phosphorylation at Thr320 of PP1α by cdc2 kinase inhibits PP1α activity.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of PP1 alpha protein.

BiowMW :~ 38 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :MAPK Erk in Growth and Differentiation Pathway(，Death Receptor Signaling，Dopamine Signaling in Parkinson\'s Disease Plathway

Alternative Name :PPP1A; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP-1A

Immunogen :Purified recombinant human PPP1A protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of PP1 alpha expression in HepG2 (A), MCF7 (B), Hela (C) whole cell lysates.