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YTHDC2 Rabbit monoclonal antibody

货号: MB66466

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66466

Product Name :YTHDC2 Rabbit monoclonal antibody

Swiss-Prot :Q9H6S0

Host :Rabbit

Reactivity :Human

Applications :WB, IP

Application_all :WB (1/500 - 1/1000), IP (1/10 - 1/50)

Background :YTH domain-containing protein 1 (YTHDC1) and YTH domain-containing protein 2 (YTHDC2) both belong to a family of proteins that bind to RNA. YTHDC1 and YTHDC2 both recognize and bind to N6-methyladenosine(m6A)-containing RNAs; binding is mediated through the YTH domains . m6A is a modification that is present at internal sites of mRNAs and some non-coding RNAs and plays a role in regulating mRNA splicing, processing, and stability. YTHDC1, also known as splicing factor YT521, regulates alternative splicing by functioning as a key regulator of exon-inclusion or exon-skipping. YTHDC1 promotes exon-inclusion by recruiting pre-mRNA splicing factor SRSF3 to regions containing m6A, while repressing exon-skipping by blocking SRSF10 binding to these same regions. Increased expression of YTHDC1 promotes malignant endometrial carcinoma (EC) through alternative splicing of vascular endothelial growth factor A (VEGF-A), resulting in an increase in VEGF-165 isoform and increased EC cell invasion. YTHDC2 functions to enhance the translation efficiency of target mRNAs and may play a role in spermatogenesis.

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of YTHDC2 protein.

BiowMW :~ 160 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Probable ATP-dependent RNA helicase YTHDC2

Immunogen :Recombinant protein of mouse YTHDC2

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of YTHDC2 expression in Hela (A), A549 (B), HL60 (C), U251 (D), U87MG (E) whole cell lysates.

免疫沉淀（IP）