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CD100 Rabbit monoclonal antibody

货号: MB66385

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :MB66385

Product Name :CD100 Rabbit monoclonal antibody

Swiss-Prot :Q92854

Host :Rabbit

Reactivity :Human

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100)

Background :Semaphorin-4D/CD100 (Sema4D) is a disulfide-linked homodimeric type 1 transmembrane glycoprotein belonging to the class IV family of membrane bound semaphorins. The extracellular domain of Sema4D contains a cysteine-rich semaphorin-like domain, an Ig-like domain, and a PSI domain . Research studies have suggested that the cytoplasmic domain has a signaling function as it is phosphorylated on serine residues . Initial studies involving Sema4D revealed that it was implicated in axon guidance within the central nervous system through binding its high affinity receptor, plexin-B1 . Sema4D function has also been extensively characterized in the immune system and is the first semaphorin found to be expressed on the surface of many types of immune cells . In the immune system, CD72 serves as a low-affinity receptor for Sema4D and research studies have shown that Sema4D not only regulates T-cell activation but is also involved in the regulation of B-cell survival and differentiation . Many of the physiologic effects of Sema4D in the immune system are regulated by a soluble extracellular domain-containing fragment generated through proteolytic cleavage .Sema4D has also been implicated in oncogenesis as research studies have demonstrated overexpression in multiple types of solid tumors . The role of Sema4D in oncogenesis, in part, has been linked to its ability to promote tumor angiogenesis , cell invasion , and immunosuppression through enhancement of myeloid derived suppressor cell function .

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of CD100 protein.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C9orf164; CD100; SEMAJ; Semaphorin-4D; A8; BB18; GR3; CD100

Immunogen :A synthetic peptide of human Semaphorin 4D

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CD100 expression in Jurkat (A) whole cell lysates.

免疫沉淀（IP）