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PRMT7 Rabbit monoclonal antibody

货号: MB66380

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66380

Product Name :PRMT7 Rabbit monoclonal antibody

Swiss-Prot :Q9NVM4

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Protein arginine N-methyltransferase 7 (PRMT7) is a member of the protein arginine N-methyltransferase (PRMT) family of proteins that catalyze the transfer of a methyl group from S-adenosylmethionine (AdoMet) to a guanidine nitrogen of arginine . The three types of PRMTs share the ability to mono-methylate arginine residues, but vary in their ability to generate differential methylation states . Mono-methylated arginine residues are further methylated by type I PRMTs to generate an asymmetric di-methyl arginine or by type II PRMTs to form a symmetric-dimethyl arginine. Type III methyltransferases are only able to mono-methylate arginine residues . Research studies indicate that PRMT7 is a type III PRMT that displays substrate specificity for an arginine-X-arginine (RXR) motif surrounded by several basic residues . PRMT7 interacts with a wide array of protein substrates and likely plays a role in many biological processes including pluripotency, neuronal differentiation, genomic instability, snRNP biogenesis, and breast cancer metastasis .

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of PRMT7 protein.

BiowMW :~ 78 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA1933; Protein arginine N-methyltransferase 7; Histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7

Immunogen :A synthetic peptide of human PRMT7

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of PRMT7 expression in K562 (A), NIH3T3 (B), Hela (C), rat muscle (D), rat pancreas (E) whole cell lysates.