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PERK Rabbit monoclonal antibody

货号: MB66377

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66377

Product Name :PERK Rabbit monoclonal antibody

Swiss-Prot :Q9NZJ5

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Protein kinase-like endoplasmic reticulum kinase (PERK) is an eIF2α kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition . ER stress increases the activity of PERK, which then phosphorylates eIF2α to promote reduced translation. Research studies have demonstrated that PERK-deficient mice have defects in pancreatic β cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress . PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain . Phosphorylation of PERK at Thr980 serves as a marker for its activation status.

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of PERK protein.

BiowMW :~ 140 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK

Immunogen :Recombinant protein of human PERK

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of PERK expression in K562 (A), C6 (B), NIH3T3 (C), Hela (D) whole cell lysates.