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Integrin beta 5 Rabbit monoclonal antibody

货号: MB66360

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66360

Product Name :Integrin beta 5 Rabbit monoclonal antibody

Swiss-Prot :P18084

Host :Rabbit

Reactivity :Human, Rat, Hamster

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins having distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling). The αVβ5 integrin is expressed in various tissues and cell types, including endothelia, epithelia and fibroblasts. It plays a role in matrix adhesion to VN, FN, SPARC and bone sialoprotein and functions in the invasion of gliomas and metastatic carcinoma cells. αVβ5 integrin plays a major role in growth-factor-induced tumor angiogenesis, where cooperative signaling by the αVβ5 integrin and growth factors regulates endothelial cell proliferation and survival.

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Integrin beta 5 protein.

BiowMW :~ 85 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics，G Protein-coupled Receptors Signaling to MAPK Erk，MAPK Erk in Growth and Differentiation Pathway，PI3K AKT signaling

Alternative Name :Integrin beta-5

Immunogen :Recombinant protein of human Integrin beta 5

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Integrin beta 5 expression in C6 (A), CHOK1 (B), Hela (C) whole cell lysates.