Product Name :GSK3 beta (Phospho-S9) Rabbit monoclonal antibody
Reactivity :Human, Mouse, Rat
Applications :WB, IHC, IF/ICC
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/100), IF/ICC (1/50 - 1/100)
Background :Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.
Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of GSK3 beta (pS9) protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Adherens Junction signaling,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer\'s Disease,ESC Pluripotency and Differentiation Signaling Pathway,ErbB HER Signaling,Translational Contral elF4 and p70 S6 Kinase,Translational Contral Regulation of elF2, Receptors Signaling to MAPK Erk,Regulation of Microtubule Dynamics,Hedgehog Signaling,Inhibition of Apoptosis,Insulin &Glucose Signaling,NF-kB Signaling,PI3K AKT signaling,Wntβ catenin signaling,MTOR signaling
Alternative Name :Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser9 of human GSK3 beta
Modification :Phosphorylation
