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LDHA Rabbit monoclonal antibody

货号: MB66291

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66291

Product Name :LDHA Rabbit monoclonal antibody

Swiss-Prot :P00338

Host :Rabbit

Reactivity :Human, Rat

Applications :WB, IHC, IF/ICC, IP

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/100), IF/ICC (1/50 - 1/100), IP (1/10 - 1/50)

Background :Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and NADH to lactate and NAD+. When the oxygen supply is too low for mitochondrial ATP production, this reaction recycles NADH generated in glycolysis to NAD+, which reenters glycolysis. The major form of LDH found in muscle cells is the A (LDHA) isozyme. The LDHA promoter contains HIF-1伪 binding sites . LDHA expression is induced under hypoxic conditions. During intensive and prolonged muscle exercise, lactate accumulates in muscle cells when the supply of oxygen does not meet demand. When oxygen levels return to normal, LDH converts lactate to pyruvate to generate ATP in the mitochondrial electron transport chain.

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of LDHA protein.

BiowMW :~ 37 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Warburg Effect

Alternative Name :L-lactate dehydrogenase A chain; LDH-A; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; LDH-M; Renal carcinoma antigen NY-REN-59

Immunogen :A synthetic peptide of human Lactate Dehydrogenase

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of LDHA expression in Jurkat (A), rat brain (B), C6 (C), Hela (D) whole cell lysates.

TXNIP Participates in the Pathogenesis of PCOS by Regulating Glycolysis in Granulosa Cells

JournalBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ApplicationIHC,WB

IF2.2

SpeciesHuman,Mouse

PMID40499496