Product Name :GSK3 beta Rabbit monoclonal antibody
Reactivity :Human, Rat, Hamster
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/100)
Background :Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β . GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization .
Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of GSK3 beta protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Adherens Junction signaling,Regulation of Microtubule Dynamics,ESC Pluripotency and Differentiation Signaling Pathway,ErbB HER Signaling,G Protein-coupled,Translational Contral elF4 and p70 S6 Kinase,Translational Contral Regulation of elF2, Receptors Signaling to MAPK Erk,Hedgehog Signaling,Inhibition of Apoptosis,Insulin &Glucose Signaling,NF-kB Signaling,PI3K AKT signaling,Wntβ catenin signaling,MTOR signaling
Alternative Name :Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
Immunogen :A synthetic peptide of human GSK3 beta
Modification :Unmodification
