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Caspase 9 Rabbit monoclonal antibody

货号: MB66284

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66284

Product Name :Caspase 9 Rabbit monoclonal antibody

Swiss-Prot :P55211

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB, IP

Application_all :WB (1/500 - 1/1000), IP (1/10 - 1/50)

Background :Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family. Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf-1. Apaf-1 mediated activation of caspase-9 involves intrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response. Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis.

Product :Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Caspase 9 protein.

BiowMW :~ 49 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer\'s Disease, Regulation of Apoptosis, Death Receptor Signaling, ErbB HER Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis

Alternative Name :MCH6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6

Immunogen :Recombinant protein of human Caspase-9

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Caspase 9 expression in NIH3T3 (A), Hela (B) whole cell lysates.